Non-Adhesive Wound Dressings for Enhanced Burn Wound Regeneration

Kimmins, Kenneth 1 ; Vegh, Andrea 1 ; Datu, Andrea 2 ; Jeschke, Marc 2,3 ; Amini-Nik, Saeid 2,3,4 ; Hatton, Benjamin 1,5

1. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto; 2. Ross Tilley Burn Centre, Sunnybrook Research Institute; 3. Institute of Medical Science, University of Toronto; 4. Department of Surgery, University of Toronto; 5. Department of Materials Science and Engineering, University of Toronto

Despite advances in healthcare, burn injuries continue to have a substantial mortality rate; the lack of effective wound healing results in secondary complications such as infection and hypermetabolic-catabolic response, often leading to death. Current standard of care includes the use of conventional wound dressings and skin grafts, but they are not actively involved in the wound healing process and susceptible to bacterial growth. Here, we report a non-adhesive silicone-based wound dressing that addresses these issues. We hypothesized that our dressing enhances wound regeneration by preventing cell adhesion to the dressing itself and bacterial infection by resisting biofilm formation. A layer of polydimethylsiloxane was rendered non-adhesive via 24-hour 10 CSt silicone oil infusion, and then fabricated into a dressing with perforations and an absorbent backing layer for wound exudate draining. Proliferation rate of fibroblast cells and the non-adhesiveness of the dressing were then evaluated in vitro. Unlike commercial wound dressings currently in the market, cell adhesion to the dressing was minimal, allowing better fibroblast proliferation with no biofilm formation. Our wound dressing is a stepping stone for a wound dressing that will decrease mortality rates and increase the quality of life of burn patients by promoting a proper regeneration of the skin tissue.